Water → HCID 21249823, compound

HRID 1531635Notes

Reaction equation

HRID 1531635 reaction equation
[C:1]([C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:22])([F:21])[F:20])[CH:13]=2)[N:4]=1)#N.[OH2:23].C(OCC)(=O)C.[OH2:30]>Cl>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([F:22])([F:21])[F:20])[CH:13]=2)[N:4]=[C:3]([C:1]([OH:30])=[O:23])[CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 21249827HCID 21249827, compoundHCID 22728543Water ethylacetate

Product 1

HCID 21249823HCID 21249823, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

2-cyano-4-methoxy-6-[3-(trifluoromethoxy)phenoxy] pyridine (1.72 g, 0.0055 mol) was suspended in about 15 ml of concentrated hydrochloric acid. The obtained suspension was stirred at about 100° C. for about 4 hours. After being allowed to stand for cooling, the obtained reaction solution was mixed with water, and then distributed in ethyl acetate-water. The organic phase separated from the solution was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated, thereby obtaining an aimed product.

Workup

  1. temperaturefor cooling
  2. customthe obtained reaction solution
  3. customThe organic phase separated from the solution
  4. washwas washed with saturated brine
  5. dry with materialdried with anhydrous sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-32e74c4d252b4a7b8c50e8cc49e3b89d
Source dataset
uspto-grants-2001_03
Patent number
US06200933B1

Reaction notes

Loading…