Acetic Acid → HCID 21249822, compound

HRID 1531636Notes

Reaction equation

HRID 1531636 reaction equation
C(C1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[N:4]=1)#N.[C:21]([OH:24])(=[O:23])[CH3:22]>Cl>[CH3:9][C:7]1[CH:6]=[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:12]=2)[N:4]=[C:22]([C:21]([OH:24])=[O:23])[CH:8]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 212498314-Methyl-6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarbonitrile

Product 1

HCID 21249822HCID 21249822, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-cyano-4-methyl-6-[3-(trifluoromethyl)phenoxy] pyridine (2.055 g, 0.0074 mol) was heated and stirred in 10 ml of concentrated hydrochloric acid and 6 ml of acetic acid at 100° C. for 5 hours. Thereafter, the obtained reaction solution was concentrated under reduced pressure. The obtained residues were mixed with water. The precipitated solids were filtered out, washed with water, and then dried.

Workup

  1. customThereafter, the obtained reaction solution
  2. concentrationwas concentrated under reduced pressure
  3. additionThe obtained residues were mixed with water
  4. filtrationThe precipitated solids were filtered out
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-5705cef1cdc1463e8e3072b9c36bef6e
Source dataset
uspto-grants-2001_03
Patent number
US06200933B1

Reaction notes

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