HCID 18326214, compound → HCID 21249837, compound

HRID 1531642Notes

Reaction equation

HRID 1531642 reaction equation
[CH3:1][N:2](CC1C=CC=CC=1)[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=[C:5]([C:20]([OH:22])=[O:21])[CH:4]=1.[H][H]>[Pd].CO>[CH3:1][NH:2][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:18])([F:19])[F:17])[CH:11]=2)[N:6]=[C:5]([C:20]([OH:22])=[O:21])[CH:4]=1

Participants

5

Reactant 2

HCID 18326214HCID 18326214, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21249837HCID 21249837, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-[methyl(phenylmethyl)amino]-6-[3-(trifluoromethyl) phenoxy] picolinic acid (0.42 g, 0.0010 mol) and a small amount of 10% palladium/carbon were added to about 30 ml of methanol. The obtained mixture was stirred at room temperature for about 10 hours in a hydrogen atmosphere. The obtained reaction solution was filtered using High-Flow Super Cell, and then concentrated, thereby obtaining an aimed product.

Workup

  1. customThe obtained reaction solution
  2. filtrationwas filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d663056d66e7478d811844901d442600
Source dataset
uspto-grants-2001_03
Patent number
US06200933B1

Reaction notes

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