反应详情

温度

70 °C

5-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid methyl ester (0.7 g, 0.0021 mol) was dissolved in 2.8 ml of ethyl alcohol. One milliliter of an aqueous solution of sodium hydroxide (0.102 g, 0.0021×1.2 mol) was added to the obtained solution. The resultant mixture was heated and stirred at 70° C. for 1.5 hours. After cooling, the obtained reaction solution was mixed with 2 ml of concentrated hydrochloric acid, thereby precipitating solids. The precipitated solids were filtered out from the solution, washed with water, and then dried.

1. temperatureAfter cooling
2. customthe obtained reaction solution
3. customprecipitating solids
4. filtrationThe precipitated solids were filtered out from the solution
5. washwashed with water
6. customdried