Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 21249836 | HCID 21249836 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Chloroform water | HCID 22418719 | — |
| Product | HCID 69992760 | HCID 69992760 | — |
Reaction Steps
2-cyano-4-methoxy-6-[2-chloro-6-(trifluoromethyl) phenoxy] pyridine (2.88 g, 0.0088 mol) was suspended in about 20 ml of concentrated hydrochloric acid and about 10 ml of acetic acid. The obtained suspension was stirred at about 100° C. for about 4 hours. After being allowed to stand for cooling, the obtained reaction solution was mixed with water, and then distributed in chloroform-water. The obtained solution was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated, thereby obtaining an aimed product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06200933B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-635252f522b140d48197ee8e6c22e8b9 |
|---|
| Source note | uspto-grants-2001_03 |
|---|
