Acetic Acid → HCID 69992760, compound

HRID 1531647Notes

Reaction equation

HRID 1531647 reaction equation
C(C1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([O:11][C:12]2[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:22])[N:4]=1)#N.O.[C:24]([OH:27])(=[O:26])[CH3:25]>Cl.C(Cl)(Cl)Cl.O>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([O:11][C:12]2[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:22])[N:4]=[C:25]([C:24]([OH:27])=[O:26])[CH:8]=1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 21249836HCID 21249836, compound

Product 1

HCID 69992760HCID 69992760, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 22418719Chloroform waterSolvent

Conditions

Temperature
100 °C

Procedure

2-cyano-4-methoxy-6-[2-chloro-6-(trifluoromethyl) phenoxy] pyridine (2.88 g, 0.0088 mol) was suspended in about 20 ml of concentrated hydrochloric acid and about 10 ml of acetic acid. The obtained suspension was stirred at about 100° C. for about 4 hours. After being allowed to stand for cooling, the obtained reaction solution was mixed with water, and then distributed in chloroform-water. The obtained solution was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated, thereby obtaining an aimed product.

Workup

  1. temperaturefor cooling
  2. customthe obtained reaction solution
  3. washThe obtained solution was washed with saturated brine
  4. dry with materialdried with anhydrous sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-635252f522b140d48197ee8e6c22e8b9
Source dataset
uspto-grants-2001_03
Patent number
US06200933B1

Reaction notes

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