Methanol → 1-(4-fluoro-phenyl)-5-hydroxymethyl-4-isopropyl-1H-pyrazole-3-carboxylic acid methyl ester

HRID 153167Notes

Reaction equation

HRID 153167 reaction equation
[BH3:23].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][n:7](-[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[c:8]([C:13](=[O:14])[OH:15])[c:9]1[CH:10]([CH3:11])[CH3:12].[CH3:29][OH:30]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][n:7](-[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[c:8]([CH2:13][OH:14])[c:9]1[CH:10]([CH3:11])[CH3:12]

Participants

5

Reactant 4

HCID 887MethanolHCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 247549721-(4-fluoro-phenyl)-4-isopropyl-1 H-pyrazole-3,5-dicarboxylic acid 3-methyl ester

Product 1

HCID 247546741-(4-fluoro-phenyl)-5-hydroxymethyl-4-isopropyl-1H-pyrazole-3-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-cf8e264611d84942905cfe3309f9f40c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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