Sodium Hydroxide → 4-Cyanophenylacetic acid

HRID 1531733Notes

Reaction equation

HRID 1531733 reaction equation
C[O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][CH:6]=1.[OH-].[Na+]>C(O)C>[C:11]([C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:13])=[O:2])=[CH:10][CH:9]=1)#[N:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 1512619Methyl (4-cyanophenyl)acetate

Product 1

HCID 795874-Cyanophenylacetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

14.2 g (0.081 mol) of methyl(4-cyano-phenyl)-acetate are dissolved in 100 ml ethanol and after the addition of 20 ml 2N sodium hydroxide solution stirred for 1 hour at ambient temperature. The solvent is distilled off, the residue is mixed with ice water and glacial acetic acid. The substance precipitated is suction filtered and dried.

Workup

  1. distillationThe solvent is distilled off
  2. additionthe residue is mixed with ice water and glacial acetic acid
  3. customThe substance precipitated
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-558571767c9f4bff80a036c8d6992d2a
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

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