Piconol → HCID 18361843, compound

HRID 1531769Notes

Reaction equation

HRID 1531769 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:19]=[C:18]([CH2:20]C)[O:17][N:16]=3)[N:4]2[N:3]=1.N1C=CC=C[C:23]=1CO>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[C:19]([CH3:23])=[C:18]([CH3:20])[O:17][N:16]=3)[N:4]2[N:3]=1

Participants

3

Reactant 2

HCID 11474PiconolHCID 18361721HCID 18361721, compound

Product 1

HCID 18361843HCID 18361843, compound

Procedure

The title-compound was prepared from 6-chloro-3-(5-ethylisoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine and 2-pyridylcarbinol using the procedure given for Example 1, 1H NMR (360 MHz, CDCl3) δ 1.42 (3H, t, J=7.6 Hz, Me), 2.93 (2H, q, J=7.5 Hz, CH2), 5.78 (2H, s, CH2O), 6.83 (1H, s, Ar—H), 7.29 (1H, m, Ar—H), 7.75-7.85 (3H, m, 3 of Ar—H), 7.99 (1H, m, Ar—H), 8.33 (1H, d, J=7.8 Hz, Ar—H), 8.64-8.72 (2H, m, Ar—H); MS (ES30) m/e 373 [MH]+.

Sources & evidence

ORD record
ord-986ba126902642b981456f1f23835929
Source dataset
uspto-grants-2001_03
Patent number
US06200975B1

Reaction notes

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