77177-22-1 → HCID 18361818, compound

HRID 1531783Notes

Reaction equation

HRID 1531783 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:19]=[CH:18][O:17][N:16]=3)[N:4]2[N:3]=1.[OH:20][CH2:21][C:22]1[N:23]=[N:24][N:25]([CH2:27][CH3:28])[CH:26]=1>>[CH2:27]([N:25]1[CH:26]=[C:22]([CH2:21][O:20][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]3=[N:12][N:13]=[C:14]([C:15]4[CH:19]=[CH:18][O:17][N:16]=4)[N:4]3[N:3]=2)[N:23]=[N:24]1)[CH3:28]

Participants

3

Reactant 2

HCID 1265435177177-22-1HCID 18361764HCID 18361764, compound

Product 1

HCID 18361818HCID 18361818, compound

Procedure

The title-compound was prepared from 6-chloro-3-(3-isoxazolyl)-1,2,4-triazolo[3,4-a]phthalazine (prepared as described in Example 34, step b) and 4-hydroxymethyl-1-ethyl-1,2,3-triazole (prepared as described in Example 98 part a), following the procedure described in Example 98, but performing the reaction at −45° C. 1H NMR (360 MHz, CDCl3) δ 1.55 (3H, t, J=7.5 Hz, CH3), 4.40 (2H, q, J=7.4 Hz, CH2), 5.78 (2H, s, CH2), 7.31 (1H, d, J=1.7 Hz, Ar—H), 7.82 (1H, m, Ar—H), 7.95 (1H, m, Ar—H), 8.27 (1H, d, J=7.8 Hz, Ar—H), 8.64-8.66 (2H, m, 2 of Ar—H), 8.69 (1H, s, Ar—H); MS (ES30) m/e 363 [MH]+; Anal. Found. C, 56.24; H, 3.70; N, 30.65. C17H14N8O2 requires C, 56.35; H, 3.89; N, 30.92%.

Workup

  1. customprepared
  2. customthe reaction at −45° C

Sources & evidence

ORD record
ord-626c4c5b81ce45c6aaea02d34eb0f1c4
Source dataset
uspto-grants-2001_03
Patent number
US06200975B1

Reaction notes

Loading…