77177-22-1 → HCID 18361818, compound

Participants

Reaction Steps

The title-compound was prepared from 6-chloro-3-(3-isoxazolyl)-1,2,4-triazolo[3,4-a]phthalazine (prepared as described in Example 34, step b) and 4-hydroxymethyl-1-ethyl-1,2,3-triazole (prepared as described in Example 98 part a), following the procedure described in Example 98, but performing the reaction at −45° C. 1H NMR (360 MHz, CDCl3) δ 1.55 (3H, t, J=7.5 Hz, CH3), 4.40 (2H, q, J=7.4 Hz, CH2), 5.78 (2H, s, CH2), 7.31 (1H, d, J=1.7 Hz, Ar—H), 7.82 (1H, m, Ar—H), 7.95 (1H, m, Ar—H), 8.27 (1H, d, J=7.8 Hz, Ar—H), 8.64-8.66 (2H, m, 2 of Ar—H), 8.69 (1H, s, Ar—H); MS (ES30) m/e 363 [MH]+; Anal. Found. C, 56.24; H, 3.70; N, 30.65. C17H14N8O2 requires C, 56.35; H, 3.89; N, 30.92%.

Provenance & Evidence