HCID 18361764, compound → HCID 18361839, compound

HRID 1531786Notes

Reaction equation

HRID 1531786 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:19]=[CH:18][O:17][N:16]=3)[N:4]2[N:3]=1.[CH2:20]([N:23]1[C:27]([CH2:28][OH:29])=[N:26][CH:25]=[N:24]1)[CH2:21][CH3:22]>>[O:17]1[CH:18]=[CH:19][C:15]([C:14]2[N:4]3[N:3]=[C:2]([O:29][CH2:28][C:27]4[N:23]([CH2:20][CH2:21][CH3:22])[N:24]=[CH:25][N:26]=4)[C:11]4[C:6]([C:5]3=[N:12][N:13]=2)=[CH:7][CH:8]=[CH:9][CH:10]=4)=[N:16]1

Participants

3

Reactant 2

HCID 18361764HCID 18361764, compoundHCID 18406849HCID 18406849, compound

Product 1

HCID 18361839HCID 18361839, compound

Procedure

The title-compound was prepared from 6-chloro-3-(isoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine (described in Example 34 part b) and 2-propyl-3-hydroxymethyl-1,2,4-triazole prepared as described in WO-A-9804559 using the procedure given for Example 71, 1H NMR (360 MHz, CDCl3) δ 0.95 (3H, t, J=7.4 Hz, Ar—H), 1.91-2.01 (2H, m, CH2), 4.34 (2H, t, J=7.0 Hz, CH2), 5.85 (2H, s, CH2), 7.28 (1H, d, J=1.7 Hz, Ar—H), 7.83 (1H, t, J=8.3 Hz, Ar—H), 7.96-8.01 (2H, m, 2 of Ar—H), 8.21 (1H, d, J=7.9 Hz, Ar—H), 8.62 (1H, s, Ar—H), 8.70 (1H, d, J=7.1 Hz, Ar—H); MS (ES30) m/e 377 [MH]+; Anal. Found. C, 57.12; H, 3.87; N, 29.49. C18H16N8O2.0.05CH2Cl2 requires C, 56.96; H, 4.26; N. 29.44%.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-6d0d953bb7a44dddb68e2d2502817764
Source dataset
uspto-grants-2001_03
Patent number
US06200975B1

Reaction notes

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