反应详情

A mixture of [3-methylphenyl]acetic acid ethyl ester (5g), N-bromosuccinimide (5 g) and benzoyl peroxide (0.1 g) in dichloromethane (200 ml) was irradiated under a 500 W halogen lamp for 6 hours. The solvent was evaporated and the residue partitioned between diethyl ether and water. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 5-10% ethyl acetate in isohexane. Yield 5.14 g.

1. customThe solvent was evaporated
2. customthe residue partitioned between diethyl ether and water
3. dry with materialThe organic phase was dried (MgSO4)
4. customevaporated
5. customPurified by chromatography
6. washeluting with 5-10% ethyl acetate in isohexane