HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → Ethyl 2-(3-(bromomethyl)phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl m-tolylacetate | HCID 96574 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 2-(3-(bromomethyl)phenyl)acetate | HCID 10563066 | — |
Reaction Steps
A mixture of [3-methylphenyl]acetic acid ethyl ester (5g), N-bromosuccinimide (5 g) and benzoyl peroxide (0.1 g) in dichloromethane (200 ml) was irradiated under a 500 W halogen lamp for 6 hours. The solvent was evaporated and the residue partitioned between diethyl ether and water. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 5-10% ethyl acetate in isohexane. Yield 5.14 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200981B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-a069ede5c390418cad67e5a7036445a8 |
| Source note | uspto-grants-2001_03 |