HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → Methyl 2-bromo-5-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-Bromo-5-methylbenzoic acid | HCID 228080 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-bromo-5-methylbenzoate | HCID 15110996 | — |
Reaction Steps
A solution of 2-bromo-5-methylbenzoic acid (10 g) in trimethylsilyl chloride (30 ml) and methanol (100 ml) was stirred at room temperature overnight and evaporated. The residue was partitioned between ethyl acetate and sodium bicarbonate solution, dried (MgSO4) and evaporated. Yield 10.1 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200981B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-03370eb2ce754607bacbfce5045e9de9 |
| Source note | uspto-grants-2001_03 |