HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → METHYL 3-(HYDROXYMETHYL)-5-NITROBENZOATE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 3-(chlorocarbonyl)-5-nitrobenzoate | HCID 74774 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | METHYL 3-(HYDROXYMETHYL)-5-NITROBENZOATE | HCID 10703703 | — |
Reaction Steps
A stirred solution of the product from step (i) (46.54 g) and sodium borohydride (13.01 g) in 1,4-dioxane (200 ml) was heated at reflux for 17 hours. The mixture was cooled and treated with triethylamine (27.9 ml), poured onto ice-water and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and evaporated. The product was recrystallised from isohexane. Yield 19.38 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200981B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-8ae2dc45fa73405cbbda1d2570d69ebf |
| Source note | uspto-grants-2001_03 |