反应详情

A stirred solution of the product from step (i) (46.54 g) and sodium borohydride (13.01 g) in 1,4-dioxane (200 ml) was heated at reflux for 17 hours. The mixture was cooled and treated with triethylamine (27.9 ml), poured onto ice-water and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and evaporated. The product was recrystallised from isohexane. Yield 19.38 g.

1. temperatureat reflux for 17 hours
2. temperatureThe mixture was cooled
3. additionpoured onto ice-water
4. extractionextracted with ethyl acetate
5. dry with materialThe combined extracts were dried (MgSO4)
6. customevaporated
7. customThe product was recrystallised from isohexane