反应详情

A mixture of the product from step (ii) (23.4 g), ammonium chloride (23 g) and iron powder (23 g) in methanol (200 ml) and water (200 ml) was heated at reflux for 1 hour. The mixture was filtered and concentrated under reduced pressure and the residue treated with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extract was dried (MgSO4) and evaporated. Yield 19.38 g.

1. temperaturewas heated
2. temperatureat reflux for 1 hour
3. filtrationThe mixture was filtered
4. concentrationconcentrated under reduced pressure
5. additionthe residue treated with saturated aqueous sodium bicarbonate
6. extractionextracted with ethyl acetate
7. dry with materialThe extract was dried (MgSO4)
8. customevaporated