反应详情

To a solution of tert-butanol (12.2 ml) in tetrahydrofuran (300 ml) at 0° C. was added n-butyllithium (52 ml) dropwise over 10 minutes. m-Toluoyl chloride (20 g) was added and the mixture heated at reflux for 1 hours. The mixture was partitioned between ethyl acetate and water and the organic phase dried (MgSO4) and evaporated. Purified by chromatography eluting with 20% dichloromethane in isohexane. Yield 14.78 g. Used directly in the next step.

1. temperaturethe mixture heated
2. temperatureat reflux for 1 hours
3. customThe mixture was partitioned between ethyl acetate and water
4. dry with materialthe organic phase dried (MgSO4)
5. customevaporated
6. customPurified by chromatography
7. washeluting with 20% dichloromethane in isohexane