Lawesson's reagent → HCID 131722450, compound

HRID 1531949Notes

Reaction equation

HRID 1531949 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([C:16]3[C:17]([S:37][CH3:38])=[N:18][C:19](=O)[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=4)[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH:21]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:48])=CC=1>C1C=CC=CC=1>[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([C:16]3[C:17]([S:37][CH3:38])=[N:18][C:19](=[S:48])[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=4)[C:26]([O:28][C:29]([CH3:32])([CH3:30])[CH3:31])=[O:27])[CH:21]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 57033613HCID 57033613, compound

Product 1

HCID 131722450HCID 131722450, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of the product from step (v) (0.46 g) and Lawesson's reagent (0.18 g) in benzene (5 ml) was heated at reflux for 2 hours. The mixture was evaporated and purified by chromatography eluting with 10% ethyl acetate in toluene. Yield 0.5 g.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customThe mixture was evaporated
  4. custompurified by chromatography
  5. washeluting with 10% ethyl acetate in toluene

Sources & evidence

ORD record
ord-5ba63cdc227c4409b8176d53dee2148d
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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