HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1531967Generated: October 30, 2026
Ethyl Acetate → N-[(1-Octyl-3-(2-hydroxyethyl)-4,6-dimethylindolin-7-yl)]-2,2-dimethylpropanamide
https://huagongshe.com/reaction/1531967
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Iodooctane | HCID 12380 | — |
| Reactant | N-[3-(2-Hydroxyethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide | HCID 22247328 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[(1-Octyl-3-(2-hydroxyethyl)-4,6-dimethylindolin-7-yl)]-2,2-dimethylpropanamide | HCID 15895568 | 13.5% |
Reaction Steps
N-[3-(2—Hydroxyethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethyl-propanamide (1.6 g) was dissolved in DMF (15 ml) and 1-iodooctane (3.9 g) and K2 CO3 (2.3 g) were added, which was followed by stirring at 70° C for 10 hr. AcOEt (200 ml) was added, and the mixture was washed with water and dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=5/1−1/2) to give 300 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06200988B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-05dd5b0604be47d89710e073a7397c02 |
|---|
| Source note | uspto-grants-2001_03 |
|---|
