反应详情

温度

70 °C

N-[3-(2—Hydroxyethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethyl-propanamide (1.6 g) was dissolved in DMF (15 ml) and 1-iodooctane (3.9 g) and K2 CO3 (2.3 g) were added, which was followed by stirring at 70° C for 10 hr. AcOEt (200 ml) was added, and the mixture was washed with water and dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=5/1−1/2) to give 300 mg of the title compound.

1. washthe mixture was washed with water
2. dry with materialdried over anhydrous sodium sulfate
3. customAcOEt was evaporated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=5/1−1/2)