HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1531978Generated: October 30, 2026
Ethyl Acetate → N-[(1-Octyl-3-(2-methoxycarbonylethyl)-4,6-dimethylindolin-7-yl)]-2,2-dimethylpropanamide
https://huagongshe.com/reaction/1531978
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Iodooctane | HCID 12380 | — |
| Reactant | N-[3-(2-methoxycarbonylethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide | HCID 22247317 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[(1-Octyl-3-(2-methoxycarbonylethyl)-4,6-dimethylindolin-7-yl)]-2,2-dimethylpropanamide | HCID 15895569 | 82.2% |
Reaction Steps
N-[3-(2-Methoxycarbonylethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide (1.0 g) was dissolved in DMF (10 ml) and 1-iodooctane (1.44 g) and K2 CO3 (830 g) were added, which was followed by stirring at 40° C. for 10 hr. AcOEt (100 ml) was added, and after washing with water, the mixture was dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=20/1−5/1) to give 1.1 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06200988B1 |
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| Source dataset | uspto-grants-2001_03 |
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| ORD ID | ord-559464f9b3654aada29441b3b8e6c328 |
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| Source note | uspto-grants-2001_03 |
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