反应详情

温度

40 °C

N-[3-(2-Methoxycarbonylethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide (1.0 g) was dissolved in DMF (10 ml) and 1-iodooctane (1.44 g) and K2 CO3 (830 g) were added, which was followed by stirring at 40° C. for 10 hr. AcOEt (100 ml) was added, and after washing with water, the mixture was dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=20/1−5/1) to give 1.1 g of the title compound.

1. washafter washing with water
2. dry with materialthe mixture was dried over anhydrous sodium sulfate
3. customAcOEt was evaporated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (eluent: benzene/AcOEt=20/1−5/1)