HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 5-(4-Aminophenoxy)-3-chloropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-(4-Nitrophenoxy)-3-chloropyridine | HCID 12109359 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-Aminophenoxy)-3-chloropyridine | HCID 12109360 | 97.4% |
Reaction Steps
To a stirred solution of 5-(4-nitrophenoxy)-3-chloropyridine (219 mg, 0.873 mmol) in EtOH (4 mL) was added SnCl2 (730 mg, 3.24 mmol). The solution was refluxed for 1.25 hr and the solvent was removed by evaporation. The resulting crude solid was purified by chromatography (97.5:2.5 CH2Cl2:MeOH) to provide 187.7 mg (78% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200995B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-e5a927a7149a43429c6a3b4078114ffd |
| Source note | uspto-grants-2001_03 |