Morpholine → 3-Methyl-6-[5-(morpholinosulphonyl)-2-n-propoxyphenyl]-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]-pyrimidin-4-one

HRID 1532067Notes

Reaction equation

HRID 1532067 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[S:8]([C:11]1[CH:12]=[CH:13][C:14]([O:31][CH2:32][CH2:33][CH3:34])=[C:15]([C:17]2[NH:18][C:19](=[O:30])[C:20]3[C:25]([CH3:26])=[N:24][N:23]([CH2:27][CH2:28][CH3:29])[C:21]=3[N:22]=2)[CH:16]=1)(=[O:10])=[O:9]>>[CH3:26][C:25]1[C:20]2[C:19](=[O:30])[NH:18][C:17]([C:15]3[CH:16]=[C:11]([S:8]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)(=[O:10])=[O:9])[CH:12]=[CH:13][C:14]=3[O:31][CH2:32][CH2:33][CH3:34])=[N:22][C:21]=2[N:23]([CH2:27][CH2:28][CH3:29])[N:24]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 1361713916-(5-chlorosulphonyl-2-n-propoxyphenyl)-3-methyl-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Product 1

HCID 1355155993-Methyl-6-[5-(morpholinosulphonyl)-2-n-propoxyphenyl]-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]-pyrimidin-4-one

Procedure

The title compound was prepared from morpholine (0.451 g, 0.0052 mol) and 6-(5-chlorosulphonyl-2-n-propoxyphenyl)-3-methyl-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (Preparation 8; 0.55 g, 0.0013 mol), according to the procedure of Example 14, and was obtained as colourless needles (0.403 g, 65%), m.p. 161-163° C., after crystallisation from ethyl acetate-hexane. Found: C,55.68; H,6.16; N,14.85. C22H29N5O5S requires C,55.56; H,6.15; N,14.73%.

Sources & evidence

ORD record
ord-a7c99106a24642b79581aa7710fb921a
Source dataset
uspto-grants-2001_03
Patent number
US06200980B1

Reaction notes

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