HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 3-Methyl-6-[5-(morpholinosulphonyl)-2-n-propoxyphenyl]-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]-pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 6-(5-chlorosulphonyl-2-n-propoxyphenyl)-3-methyl-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | HCID 136171391 | — |
| Product | 3-Methyl-6-[5-(morpholinosulphonyl)-2-n-propoxyphenyl]-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]-pyrimidin-4-one | HCID 135515599 | — |
Reaction Steps
The title compound was prepared from morpholine (0.451 g, 0.0052 mol) and 6-(5-chlorosulphonyl-2-n-propoxyphenyl)-3-methyl-1-n-propyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (Preparation 8; 0.55 g, 0.0013 mol), according to the procedure of Example 14, and was obtained as colourless needles (0.403 g, 65%), m.p. 161-163° C., after crystallisation from ethyl acetate-hexane. Found: C,55.68; H,6.16; N,14.85. C22H29N5O5S requires C,55.56; H,6.15; N,14.73%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200980B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-a7c99106a24642b79581aa7710fb921a |
| Source note | uspto-grants-2001_03 |