反应详情

温度

175 °C

A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (1.3 g), anhydrous potassium acetate (0.34 g) and thiourea (0.96 g) was heated at 170-180° C. for 2 hours. After digestion with water the mixture was filtered and the solid was dissolved in 1 Normal sodium hydroxide solution then re-precipitated by the addition of acetic acid. The dried solid was digested with chloroform and with ethanol to leave 1.12 g of a crude product. Repeated recrystallisations from dimethylformamide, 2-methoxyethanol, and acetic acid yielded the title compound, 0.32 g, m.p. 305-307° C.

1. filtrationAfter digestion with water the mixture was filtered
2. dissolutionthe solid was dissolved in 1 Normal sodium hydroxide solution
3. customthen re-precipitated by the addition of acetic acid
4. customto leave 1.12 g of a crude product
5. customrecrystallisations from dimethylformamide, 2-methoxyethanol, and acetic acid