Hydrochloric Acid → 2-(2-Propoxyphenyl)-8-methylthiopurin-6-one

HRID 1532080Notes

Reaction equation

HRID 1532080 reaction equation
[CH3:1]I.[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([SH:22])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5].[OH-].[Na+].Cl>>[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:21]=[C:20]2[C:16](=[N:17][C:18]([S:22][CH3:1])=[N:19]2)[C:15](=[O:23])[N:14]=1)[CH2:4][CH3:5]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178458302HCID 178458302, compound

Product 1

HCID 212507942-(2-Propoxyphenyl)-8-methylthiopurin-6-one

Procedure

Methyl iodide (0.5 g) was added to a stirred solution of 2-(2-propoxyphenyl)-8-mercaptopurin-6-one (1.0 g) in 1 Normal sodium hydroxide solution (8 ml). After 2.5 hours at room temperature the solution was neutralised with dilute hydrochloric acid to give the crude product which was recrystallised three times from aqueous ethanol to give the title compound, 0.32 g, m.p. 245-247° C.

Workup

  1. customto give the crude product which
  2. customwas recrystallised three times from aqueous ethanol

Sources & evidence

ORD record
ord-0ce57314bf4c4a25ba63ca2aeb99103f
Source dataset
uspto-grants-2001_03
Patent number
US06200980B1

Reaction notes

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