反应详情

A mixture of fuming nitric acid (0.23 ml) and sulphuric acid (4 ml) was added dropwise to a stirred solution of 2-(2-propoxyphenyl)purin-6-one (1.0 g) in sulphuric acid (4 ml) at 0 to -5° C. The temperature was maintained between −5° C. and +4° C. for 20 hours and then the mixture was poured into ice-water. The filtered solution was treated with concentrated ammonium hydroxide to pH 9 to give a crude product, 0.55 g. Recrystallisation twice from aqueous ethanol then once from acetonitrile gave the title compound, 0.2 g, m.p. 254-256° C.

1. temperatureThe temperature was maintained between −5° C. and +4° C. for 20 hours
2. customto give a crude product, 0.55 g
3. customRecrystallisation twice from aqueous ethanol