反应详情

A stirred mixture of methyl 4-methoxysalicylate (25 g), bromopropane (15.6 ml), potassium iodide (2.82 g) and anhydrous potassium carbonate (27.53 g) was heated under reflux for 48 hours. The cooled reaction mixture was filtered and the filtrate was evaporated under reduced pressure to yield an oil which was dissolved in diethyl ether (200 ml). The ethereal solution was extracted with aqueous sodium hydroxide to remove unreacted starting material and the organic phase was then washed with water and brine, dried (magnesium sulphate) and evaporated under reduced pressure to yield methyl4-methoxy-2-propoxy-benzoate, 22.45 g.

1. temperaturewas heated
2. temperatureunder reflux for 48 hours
3. customThe cooled reaction mixture
4. filtrationwas filtered
5. customthe filtrate was evaporated under reduced pressure
6. customto yield an oil which
7. extractionThe ethereal solution was extracted with aqueous sodium hydroxide
8. customto remove unreacted
9. washthe organic phase was then washed with water and brine
10. dry with materialdried (magnesium sulphate)
11. customevaporated under reduced pressure