HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | HCID 18409955 | HCID 18409955 | — |
| Product | 2-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one | HCID 21250787 | — |
Reaction Steps
In a similar manner to Example 49 reaction of 2-(2-propoxyphenyl)purin-6-one (0.81 g) with chlorosulphonic acid (4.5 ml), followed by reaction with methylamine in industrial methylated spirit (33%, 50 ml) yielded the title compound, 0.49 g, m.p. 245-246° C. (recrystallised twice from aqueous ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200980B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-f4a5838f8f464563a0344c9d51b2e8e7 |
| Source note | uspto-grants-2001_03 |