2-Bromopyridine → HCID 135738571, compound

HRID 1532102Notes

Reaction equation

HRID 1532102 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Br[C:9]1[CH:10]=[CH:11][C:12]([O:29][CH2:30][CH3:31])=[C:13]([C:15]2[NH:16][C:17](=[O:28])[C:18]3[N:23]([CH3:24])[N:22]=[C:21]([CH2:25][CH2:26][CH3:27])[C:19]=3[N:20]=2)[CH:14]=1>>[CH2:30]([O:29][C:12]1[CH:11]=[CH:10][C:9]([N:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH2:2]2)=[CH:14][C:13]=1[C:15]1[NH:16][C:17](=[O:28])[C:18]2[N:23]([CH3:24])[N:22]=[C:21]([CH2:25][CH2:26][CH3:27])[C:19]=2[N:20]=1)[CH3:31]

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 1357385545-(5-Bromo-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-D]pyrimidin-7(6H)-one

Product 1

HCID 135738571HCID 135738571, compound

Procedure

The title compound was prepared from 2-bromopyridine and 5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, following the procedure described in Example 82, and was obtained as an off-white solid (33%), m.p. 216-218° C. Found: C,67.61; H,5.81; N,17.63. C22H23N5O2 requires C,67.85; H,5.95; N,17.98%.

Sources & evidence

ORD record
ord-faaa45119ef6466bb81cfd32e5bc147c
Source dataset
uspto-grants-2001_03
Patent number
US06200980B1

Reaction notes

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