Toluene → 4-(Pyrimidin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][n:6][cH:7]1.[CH3:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1.[NH2:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:13][CH2:14]1.[O:24]=[C:25]([CH:26]=[CH:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[CH:34]=[CH:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[O:42]=[C:43]([CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)[CH:52]=[CH:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1.[O:60]=[C:61]([CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1)[CH:70]=[CH:71][c:72]1[cH:73][cH:74][cH:75][cH:76][cH:77]1.[Pd:22].[Pd:23]>>[c:2]1([NH:8][CH:9]2[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:13][CH2:14]2)[cH:3][n:4][cH:5][n:6][cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-c816caebe87b4b5d92df0110d60ad86b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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