反应详情

To a stirred, −10° solution of the crude product from Step A (1.233 grams) in methylene chloride (12 mL) was added 48% HBr dropwise (1.14 mL). After gas evolution ceased, the reaction was stirred for 15 minutes at room temperature. The reaction was partitioned between isopropyl acetate and water. The organic was washed once with water, dried over magnesium sulfate and filtered. Evaporation afforded an oil containing the title compound which was used without further processing.

1. customThe reaction was partitioned between isopropyl acetate and water
2. washThe organic was washed once with water
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customEvaporation
6. customafforded an oil