Ethanolamine → 3-[(2-Hydroxyethyl)amino]butanoic acid

HRID 1532250Notes

Reaction equation

HRID 1532250 reaction equation
[C:1]([OH:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7]([CH2:9][NH2:10])[OH:8]>N1C=CC=CC=1>[OH:8][CH2:7][CH2:9][NH:10][CH:3]([CH3:4])[CH2:2][C:1]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 637090Crotonic Acid

Product 1

HCID 212517133-[(2-Hydroxyethyl)amino]butanoic acid

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 86 g of crotonic acid (1 mole) and ethanolamine (1 mole) in pyridine (200 ml) was refluxed for 2-3 hours and subsequently cooled. The resulting product was filtered and recyrstallized to yield the title compound having a m.p. (melting point) of 178-180° C. (compound 1.1, List of Compounds).

Workup

  1. temperaturesubsequently cooled
  2. filtrationThe resulting product was filtered

Sources & evidence

ORD record
ord-debaff6b009e4b08829fa69e98a3e7ea
Source dataset
uspto-grants-2001_03
Patent number
US06201023B1

Reaction notes

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