Benzyl chloroformate → HCID 140420281, compound

HRID 1532354Notes

Reaction equation

[C:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([CH2:15][CH2:16][C@@H:17]3[CH2:21][CH2:20][CH2:19][N:18]3[C:22]([C@H:24]3[CH2:28][CH2:27][CH2:26][N:25]3[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])=[O:23])[N:10]2[CH2:13][CH3:14])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].[CH2:35]([O:42]C(Cl)=O)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:13]([N:10]1[C:11]2[C:7](=[CH:6][CH:5]=[C:4]([C:1](=[NH:2])[NH:3][C:35]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[O:42])[CH:12]=2)[CH:8]=[C:9]1[CH2:15][CH2:16][C@@H:17]1[CH2:21][CH2:20][CH2:19][N:18]1[C:22]([C@H:24]1[CH2:28][CH2:27][CH2:26][N:25]1[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])=[O:23])[CH3:14]

Participants

Reactant 2

HCID 10387Benzyl chloroformate

HCID 53949705HCID 53949705, compound

Product 1

HCID 140420281HCID 140420281, compound

Procedure

60 mg of ethyl 2-[(R)-2-[[(S)-2-[2-(6-amidino-1-ethylindol-2-yl)ethyl]pyrrolidinyl]carbonyl]pyrrolidinyl]acetate obtained in Example 60 was reacted with 24 μl of benzylchloroformate according to the same procedure as Example 154 to obtain 64 mg of the title compound.

Sources & evidence

ORD record: ord-f639e351960a4893a8f7763f3b6619ae
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06201006B1

Reaction notes

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