Hydrochloric Acid → HCID 86756534, compound

HRID 1532506Notes

Reaction equation

HRID 1532506 reaction equation
[F:1][CH:2]([F:38])[O:3][C:4]1[CH:5]=[C:6]([CH:14]([C:23]2[CH:24]=[N:25][C:26]([N:29]([CH3:37])[CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:27][CH:28]=2)[CH2:15][C:16]2[CH:21]=[CH:20][N+:19]([O-:22])=[CH:18][CH:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH:11]([F:13])[F:12].[ClH:39]>O1CCOCC1>[ClH:39].[F:38][CH:2]([F:1])[O:3][C:4]1[CH:5]=[C:6]([CH:14]([C:23]2[CH:24]=[N:25][C:26]([N:29]([CH3:37])[CH2:30][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[CH:27][CH:28]=2)[CH2:15][C:16]2[CH:21]=[CH:20][N+:19]([O-:22])=[CH:18][CH:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH:11]([F:13])[F:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21251090HCID 21251090, compound

Product 1

HCID 86756534HCID 86756534, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 4-2-[3,4-bis(difluoromethoxy)phenyl]-2-[6-(N-methyl-N-benzylamino)3-pyridyl]ethyl}pyridine-N-oxide from Example 56 (150 mg, 0.284 mmol) in 3 mL of dioxane was added 0.57 mL (0.568 mmol) of a 1 N solution of HCl in dioxane. The solution was stirred at room temperature for 30 minutes and the formation of a gum was observed. The heterogeneous mixture was sonicated and the dioxane was removed under reduced pressure. The residue was washed 2 times with dry ether and pumped under high vacuum to afford the title compound as a yellow solid (160 mg, 94%).

Workup

  1. customThe heterogeneous mixture was sonicated
  2. customthe dioxane was removed under reduced pressure
  3. washThe residue was washed 2 times with dry ether

Sources & evidence

ORD record
ord-7af3d69dd06b44a782b2c194b825a0d9
Source dataset
uspto-grants-2001_03
Patent number
US06200993B1

Reaction notes

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