反应详情

0.908 g of 4-(4-bromo-2-fluorophenylethynyl)-4,4′-dipentylbicyclohexyl (obtainable by Wittig reaction of 4,4′-dipentylbicyclohexyl-4-carbaldehyde with 4-bromo-2-fluorobenzyltriphenylphosphonium bromide, addition of bromine onto the resultant alkene and subsequent dehydrobromination using a base), 0.715 g of 4-ethynyl-4,4′-dipentylbicyclohexyl and 0.104 g of tetrakis-(triphenylphosphine)palladium(0) are stirred overnight at 80° C. in 5 ml of pyrrolidine. Conventional work-up gives 4-[4-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-2-fluorophenylethynyl]-4,4′-dipentylbicyclohexyl (C 177 I).