反应详情

Anhydrous K2CO3 (21.9 g, 0.159 mol) and methyl iodide (10.8 mL, 0.178 mol) were added to a solution of 2,5-dichlorophenol (23.5 g, 0.144 mol) in 215 mL acetone. The reaction was allowed to stir at room temperature for 20 hours, then filtered through a celite pad. The filtrate was concentrated to a residue which was taken up in diethylether. The ether solution was washed with 10% NaHSO3, water, several portions of 1 M NaOH, and brine, then dried with anhydrous Na2SO4. Upon filtration and concentration, the residue was distilled (8 mm Hg, 110° C.) to yield 23.7 g (93.5%) of a light yellow oil.

1. filtrationfiltered through a celite pad
2. concentrationThe filtrate was concentrated to a residue which
3. washThe ether solution was washed with 10% NaHSO3, water, several portions of 1 M NaOH, and brine
4. dry with materialdried with anhydrous Na2SO4
5. filtrationUpon filtration and concentration
6. distillationthe residue was distilled (8 mm Hg, 110° C.)