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HRID1532610

反应详情

EQUATION

反应方程式

HRID 1532610 的结构方程式

REACTANTS

反应物

4
结构：C[Si](C)(C)OS(=O)(=O)C(F)(F)F
HCID65367

Methanesulfonic acid, trifluoro-, trimethylsilyl ester

C4H9F3O3SSi

结构：CC(=O)OC[C@@H]1O[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
HCID908100

1,2,3,5-Tetra-O-acetyl-beta-L-ribofuranose

C13H18O9

结构：C/C(=N\[Si](C)(C)C)O[Si](C)(C)C
HCID6913588

未命名化合物

结构：CC(C)NC1Nc2cccc(Cl)c2N1Cl
HCID22995452

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)OC[C@@H]1O[C@H](N2c3cccc(Cl)c3N(Cl)C2NC(C)C)[C@@H](OC(C)=O)[C@H]1OC(C)=O
HCID57222824

未命名化合物

收率 56.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

3,4-Dichloro-2-(isopropylamino)-1H-benzimidazole (2.01 g, 7.31 mmol), N,O-bis(trimethylsilyl)acetamide (2.0 mL, 1.65 g, 8.09 mmol), trimethylsilyl trifluoromethanesulfonate (0.9 mL, 1.06 g, 4.50 mmol), 1,2,3,5-tetra-O-acetyl-beta-L-ribofuranose (3.03 g, 9.52 mmol) and 1,2-dichloroethane (35 mL) were used according to general procedure II. The product was purified by silica gel chromatography using 95:5 dichloromethane/acetonitrile to afford 2.08 g (56%) of a yellow foam. MS (EI): m/z 502.0 (M+H).

WORKUP

后处理

  1. customThe product was purified by silica gel chromatography