反应详情

Add 2-(aminomethyl)benzimidazole, dihydrochloride, hydrate (18.50 g) to a solution of potassium hydroxide (9.50 g) in methanol (400 mL). Stir the resulting mixture at room temperature for 30 minutes, filter, and concentrate the filtrate in vacuo. Extract the residue with EtOAc (5×500 mL) and filter. Concentrate the filtrate in vacuo to give the title compound as a white solid (9.60 g).

1. filtrationfilter
2. concentrationconcentrate the filtrate in vacuo
3. extractionExtract the residue with EtOAc (5×500 mL)
4. filtrationfilter
5. concentrationConcentrate the filtrate in vacuo