HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1H-Benzimidazole-2-methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (1H-benzo[d]imidazol-2-yl)methanamine dihydrochloride | HCID 2723957 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1H-Benzimidazole-2-methanamine | HCID 145820 | — |
Reaction Steps
Add 2-(aminomethyl)benzimidazole, dihydrochloride, hydrate (18.50 g) to a solution of potassium hydroxide (9.50 g) in methanol (400 mL). Stir the resulting mixture at room temperature for 30 minutes, filter, and concentrate the filtrate in vacuo. Extract the residue with EtOAc (5×500 mL) and filter. Concentrate the filtrate in vacuo to give the title compound as a white solid (9.60 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06204282B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-7eca397109b648409ed376512f9dee50 |
| Source note | uspto-grants-2001_03 |