HCID 9915531, compound → HCID 9915530, compound

HRID 1532660Notes

Reaction equation

HRID 1532660 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:44])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]>C(OCC)(=O)C>[ClH:1].[CH3:44][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]

Participants

4

Reactant 2

HCID 9915531HCID 9915531, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9915530HCID 9915530, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.19 ml) was added to a solution containing ethyl 1-[3-(dimethylamino)propyl]-2-heptadecyl-1H-benzimidazole-5-carboxylate (0.38 g) in ethyl acetate (4 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (0.29 g) as grayish yellow solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-99c9dcf5e1604cf388058dd30aa799c6
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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