HCID 22013743, compound → 3-Amino-4-[[3-(dimethylamino)propyl]amino]-N-methylbenzamide

HRID 1532663Notes

Reaction equation

HRID 1532663 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([NH:13][CH3:14])=[O:12])=[CH:9][C:8]=1[N+:17]([O-])=O>C(O)C.[C].[Pd]>[NH2:17][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:7]=1[NH:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:20])[CH3:1])[C:11]([NH:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 22013743HCID 22013743, compound

Product 1

HCID 220137513-Amino-4-[[3-(dimethylamino)propyl]amino]-N-methylbenzamideYield 97.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% of palladium-carbon (0.40 g) was added to a solution containing 4-{[3-(dimethylamino)propyl]amino}-N-methyl-3-nitrobenzamide (1.88 g) in ethanol (30 ml) and the mixture was stirred for 14 hours under a hydrogen gas atmosphere at room temperature. After the catalyst was removed out by filtration, the filtrate was concentrated, thereby yielding the entitled compound (1.63 g) as purple solid.

Workup

  1. customAfter the catalyst was removed out by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-65a0887e64a645d8813d9193c5082e33
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

Loading…