HCID 9871822, compound → HCID 9871821, compound

HRID 1532665Notes

Reaction equation

HRID 1532665 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:43])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]>C(OCC)(=O)C>[ClH:1].[CH3:43][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]

Participants

4

Reactant 2

HCID 9871822HCID 9871822, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9871821HCID 9871821, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.45 ml) was added to a solution containing 1-[3-(dimethylamino)propyl]-2-heptadecyl-N-methyl-1H-benzimidazole-5-carboxamide (0.90 g) in ethyl acetate (10 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (0.70 g) as grayish yellow solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-1bac97c5a069427fa5bd5d7c363b41f5
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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