HCID 9849308, compound → HCID 9872241, compound

HRID 1532670Notes

Reaction equation

HRID 1532670 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:44])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([N:24]([CH3:26])[CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]>C(OCC)(=O)C>[ClH:1].[CH3:44][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([N:24]([CH3:26])[CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]

Participants

4

Reactant 2

HCID 9849308HCID 9849308, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9872241HCID 9872241, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.20 ml) was added to a solution containing 1-[3-(dimethylamino)propyl]-2-heptadecyl-N,N-dimethyl-1H-benzimidazole-5-carboxamide (0.41 g) in ethyl acetate (4 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with a mixed solution of n-hexane-ethyl acetate, thereby yielding the entitled compound (0.32 g) as grayish yellow solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with a mixed solution of n-hexane-ethyl acetate

Sources & evidence

ORD record
ord-920590710b4f449b9d0fd7367baf7dc0
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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