Ethanol → HCID 9915090, compound

HRID 1532683Notes

Reaction equation

HRID 1532683 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:43])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([C:16]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:19]2[CH:39]=[CH:40][CH:41]=[CH:42][C:18]=2[N:17]=1)=[O:15].C(O)C>C(OCC)(=O)C>[ClH:1].[CH3:43][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([C:16]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:19]2[CH:39]=[CH:40][CH:41]=[CH:42][C:18]=2[N:17]=1)=[O:15]

Participants

5

Reactant 3

HCID 702EthanolHCID 9892129HCID 9892129, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9915090HCID 9915090, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.25 ml) was added to a solution containing N-[3-(dimethylamino)propyl]-1-octadecyl-1H-benzimidazole-2-carboxamide (0.499 g) in ethyl acetate (5 ml) and stirred for 10 minutes at room temperature. The reaction mixture, with ethanol (0.3 ml) and ethyl acetate (1 ml) added thereto, was dissolved by heating and then cooled naturally. The depositing crystals were collected by filtration, thereby yielding the entitled compound (0.419 g) as white solid.

Workup

  1. dissolutionwas dissolved
  2. temperatureby heating
  3. temperaturecooled naturally
  4. filtrationThe depositing crystals were collected by filtration

Sources & evidence

ORD record
ord-1b2a74fe1054403e96600c9761bba408
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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