1-Methylpiperazine → HCID 9828496, compound

HRID 1532684Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:8]([N:26]1[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[N:28]=[C:27]1[C:35](OCC)=[O:36])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:35]([C:27]2[N:26]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[N:28]=2)=[O:36])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 22013732HCID 22013732, compound

Product 1

HCID 9828496HCID 9828496, compoundYield 59.6%

Conditions

Temperature: 75 °C

Procedure

1-Methylpiperazine (1.811 g) was added to ethyl 1-octadecyl-1H-benzimidazole-2-carboxylate (1.601 g) and the mixture was stirred for 48 hours at 75° C. The reaction mixture was purified by silica gel column chromatography (silica gel 60 g, chloroform:methanol=1:0-50:1), thereby yielding the entitled compound (1.070 g) as pale yellow solid.

Workup

customThe reaction mixture was purified by silica gel column chromatography (silica gel 60 g, chloroform:methanol=1:0-50:1)

Sources & evidence

ORD record: ord-33301d539cb246ffb81110665a7f3088
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06204264B1

Reaction notes

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