Ethanol → HCID 9828495, compound

HRID 1532685Notes

Reaction equation

HRID 1532685 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[N:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:20]3[CH:40]=[CH:41][CH:42]=[CH:43][C:19]=3[N:18]=2)=[O:16])[CH2:11][CH2:10]1.C(O)C>C(OCC)(=O)C>[ClH:1].[CH3:8][N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[N:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:20]3[CH:40]=[CH:41][CH:42]=[CH:43][C:19]=3[N:18]=2)=[O:16])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 702EthanolHCID 9828496HCID 9828496, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9828495HCID 9828495, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.18 ml) was added to a solution containing 2-[(4-methylpiperazinyl)carbonyl]-1-octadecyl-1H-benzimidazole (0.348 g) in ethyl acetate (4 ml) and the mixture was stirred for 15 minutes at room temperature. The reaction mixture, with ethanol (1 ml) and ethyl acetate (4 ml) added thereto, was dissolved by heating, and then cooled with ice. The depositing crystals were collected by filtration, thereby yielding the entitled compound (0.318 g) as white solid.

Workup

  1. dissolutionwas dissolved
  2. temperatureby heating
  3. temperaturecooled with ice
  4. filtrationThe depositing crystals were collected by filtration

Sources & evidence

ORD record
ord-e6cf557529fc4dc0adbbd1322c27ed51
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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